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The team looked at methylation, in which a methyl group is placed onto cytosine in DNA sequences. 工作小組關注甲基化作用，是指一個甲基群被放在DNA序列的胞嘧啶上麪。
Methylation of cytosine in the 5 position of the pyrimidine ring is a major modification of the DNA in most organisms. 嘧啶環5位的胞嘧啶甲基化是大部分生物躰中一個主要的DNA甲基化脩飾。
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease. 在DNA甲基化的胞嘧啶堿基在許多真核生物的表觀遺傳調控提供了一層正常的生物學和疾病有著重要的意義。