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OBJECTIVE:To study the synthesis of clodronate. 目的:对氯屈膦酸二钠的合成工艺进行了研究。
OBJECTIVE:To study the synthesis of clodronate. 目的:对氯屈膦酸二钠的合成工艺进行了研究。
Objective To formulate an original craft for industrial production of Clodronate. 目的结合工业化生产条件,制定氯膦酸二钠新合成工艺。
Methods Clodronate was synthesized by steps of methylenenation,Chloration, acid hydrolysis and salitying from dibromomethane and triethylphosphite. 方法以二溴甲烷和亚膦酸三乙酯为原料,经亚甲基化、氯化、酸水解和成盐反应得到氯膦酸二钠。
METHODS:Clodronate was synthesized by steps of condensation,chloration,pyrolysis and salifying from dibromomethane and triisopropyl phosphite. 方法:以二溴甲烷和亚膦酸三异丙酯为原料,经缩合、氯化、热裂解和成盐反应得到氯屈膦酸二钠。